Obese mums trial drug to make baby smaller

It has frequently been discussed in the media and in medical research that obese women are not only likely to have larger babies but that they are more likely to require a caesarean (and that caesarean delivery is ‘riskier’ for obese women).

Patrick O’Brien (RCOG)  said “When you are overweight in pregnancy you are at increased risk of just about every complication you can think of.”

While women have long been encouraged to eat sensibly rather than excessively when pregnant, dieting once pregnant is strongly discouraged. The difficulty is that an ever increasing number of women start their pregnancy already obese and unable to take significant dietary action. Not only this but for some women, a life time of eating habits can feel impossible to alter even when the risks to an unborn baby are explained.

The Telegraph  reported on a trial starting back in 2012 which involved 400 women in Coventry, Liverpool, Sheffield and Edinburgh using a drug (Metformin) traditionally reserved for diabetic women to restrict the growth of their unborn baby. Half the group took the drug , the other half received a placebo.

The senior lecturer in obstetrics leading the trial, Dr Weeks explained some of the reason behind the investigation saying “The difficulty comes when you have been living in a particular way for years that is not healthy…To suddenly change to a different lifestyle is not easy to do.”

Will Williams, scientific advisor for All About Weight (a weight loss organisation) express concerns about the implications of treating obesity issues in this way. The concern being not only that is there no information about the long term effects on children of having been exposed to these drugs inutero but also that resorting to pills to reduce foetus weight “is unlikely to break the cycle of an unhealthy lifestyle leading to overweight children and the continuing rise of obesity and diabetes in the general population.”

I will report back when the results are released, but the earliest this will be is 3 years from now when the trial completes.

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Delay hearing tests for caesarean babies

A study in Israel has found that there is an increased likelihood of babies delivered via caesarean failing their initial hearing test.

Traditionally this test is carried out on babies within the first 24 hours of delivery, but the study reveals that around 20% of babies delivered by caesarean are likely to fail this test, as compared to only 7% of those delivered vaginally. (Though it is worth noting that the failure rate is higher in general for all babies tested within the first 24 hours).

However, and it is a BIG however, the study showed that on re-testing the results normalised over subsequent days and most of these same babies then went on to pass the hearing test. Within the group (10/483) that continued to fail, 5 were caesarean deliveries and 5 were vaginal deliveries and with further testing the majority of these tested subsequently passed too.

What this study shows is that “There is nothing worrisome here for parents” so says Dr Woo, a paediatrician at the University of California, Los Angeles, Medical Centre in Santa Monica. The problem is often transient, and if the first test were done three or four days after birth instead, the results would likely be very different.

At the very least parents should be aware of this ‘effect’ and ideally defer the first hearing test until after the first 48 hours to avoid the worry that may be caused by early testing.

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Study finds women lack info on labour versus repeat caesarean

A recent study from the US suggests that women do not know enough about their birth options prior to making decisions about the way in which they will attempt birth following a previous caesarean. No surprises there.

But what is particularly worrying is not simply that women don’t know even basic information  but that a significant number are having to go ahead and make life changing decisions regardless.

As Berstein points out “they [VBAC and repeat CS] are both safe options” but each mode has risks these are different and need to be weighed up by Mum. They can only do this if they have all relevant information.

For example the likelihood of achieving a VBAC (Vaginal Birth After Caesarean)  is around 75% but nearly three quarters of the women interviewed in this study couldn’t hazard a guess at the VBAC success rate. Despite this over half had already opted for a VBAC regardless. (Incidentally a 75% success rate is interpreted by many as great odds, but it is worth remembering that for others, particularly those who have experienced a traumatic birth previously, it might leave enough uncertainty to lead them to request a repeat caesarean).

Unfortunately Bernsteins advice to women for tackling such gaps in their knowledge is to “have a really good discussion of your options with your OB…Don’t just read about it online or listen to your friends.” I have a several problems with this. Such an approach assumes:

  • That the practitioner has sufficient time to spend giving the mother all the information she needs to make a truly informed decision
  • That the mother can take in all the information during the appointment. That she can ask useful/probing questions pertinent to her specific concerns as the information is revealed
  • That the practitioner is willing and able to give the mother an unbiased account of her options. It is unfortunately the case that both personal opinion and hospital/surgery policies sometimes get in the way of this

In addition, while this study is important for highlighting the poor level of information support some women are getting during the antenatal period, this is yet another study that takes as it’s starting point the idea that poor education is causing women to plan a repeat caesarean. Despite Berstein’s comment that “they are both safe options” there appears to be the preconception that caesarean birth would be avoided if only women were better educated. There does not appear to be any space for the idea that with balanced information about comparative risks some women might actually choose a caesarean.

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Weight and blood sugar implications for mother and baby

Women have long been encouraged to eat sensibly rather than excessively when pregnant. While it has been known for sometime that obesity tends to be linked with a greater risk of complications a study published in the New England Journal of Medicine suggests that even women with ‘slightly elevated weight’ (not presenting with diabetes) but who have higher levels of glucose in the blood are at increased risk of carrying a large baby and thereby at increased risk of complications which may result in injury to the baby during vaginal delivery or in the need for a caesarean delivery.

Tests during pregnancy typically look for diabetic and obesity indicators but this research suggests that there is a group of women outside of these indicators who may also be at risk of complications.

Preparing for the possibility of medical intervention should, in my opinion, be a formal part of everyone’s antenatal education as we never truly know what is going to happen on the day. These result emphasise the fact that there is yet another group of women for whom this is essential – unfortunately at present most of them do not know that they fall into this category.

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Be informed when choosing a caesarean

While I am in danger of banging on about this too many times I think I will probably continue to do so for the foreseeable future. Knowledge is power and with that comes a feeling of control.

Feeling in control is a key component in retrospectively perceiving an event as positive. If we felt out of control, that things were just done to us without our consent or without a feeling that we participated in the decision-making, we are significantly more likely to view that event negatively.

This is never more true than during birth where things can quickly change and our feeling of control disappear in a breath. I believe it is essential that women are armed with as much information going into birth as they feel they can cope with. It is great therefore to be able to tell you about another book aiming to support women in just that…

‘Choosing Cesarean’ by Magnus Murphy MD and Pauline McDonagh Hull

It focuses on caeasrean birth as the title suggests but does not set out to advocate caesarean birth for all women. Instead it simply proposes that it is legitimate for women to make an informed choice in favour of a planned caesarean even where there is no medical need. They argue that all vaginal births are essentially a ‘trial of labour’ (traditionally this term has been used only in relation to VBAC) and that being prepared for a variety of outcomes is essential. They believe that information and understanding options is key to decision-making and key to coping if the plan needs to change.

“Women are being sold the natural approach as though it is something tangible they can have-just as long as they follow advice, prepare for the big day, and avoid any unnecessary medical interventions that might derail this most desirable outcome. But no matter how good the birth preparation and no matter how ideal the birth setting, doctors and midwives are still only able to optimize women’s chances of spontaneous vaginal birth-not predict or guarantee them. An injection of realism wouldn’t go amiss sometimes.”

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Why do women opt for a repeat caesarean when they could have a VBAC

New research, suggests that the opinion of the practitioner strongly influences the decision a woman will make about the mode of birth she will request.

BERNSTEIN, MATALON-GRAZI and ROSENN wanted to investigate why it was that so many women were choosing to undergo a repeat caesarean rather than a ‘trial of labour’ also known as a VBAC (Vaginal Birth After Caesarean).

They found that “When patients perceived their providers as having a preference for ERCS [repeat caesarean], very few chose TOLAC [VBAC] whereas the majority chose TOLAC if this was their provider’s preference.”

Even though the sample size was relatively small (155 women and 3/4 were educated to degree level and over the age of 30) the trend was very clear. Practitioner opinion still heavily influenced the decision the woman then went on to make. Interestingly when the woman was not aware of the practitioner expressing any particular preference the split of who chose what was exactly 50:50.

More alarming perhaps is that researchers found that regardless of which birth mode the woman chose she had a woefully inadequate level of knowledge about both the benefits and the risks of her preferred choice.

The multi-choice questionnaire assessed the woman’s level of understanding of the mode of birth they were to undergo and despite the fact that they had all received prenatal care and counselling they were unable to accurately answer such questions as:

  • If I were to try for a trial of vaginal labor, my overall chances of success are…
  • If I try for a vaginal delivery (VBAC), the risk that my uterus will rupture (opening of the uterine scar) is…
  • The reason for my previous cesarean section is an important factor in determining my chances of a successful vaginal delivery…

ACOG (American College of Obstetricians and Gynecologists) clearly define informed consent and this study reveals that women are not being given the level of unbiased, informative material they require in order to be able to genuinely make an informed decision.

As researcher point out “Informed consent, is defined as a process of communication whereby a patient is enabled to make an informed and voluntary decision about accepting or declining medical care and has become a mainstay of contemporary medical practice. It is viewed by many as a collaborative process between physician and patient intended to facilitate the patient’s autonomy in the process of ongoing choices. Our respondents showed insufficiencies in the area of comprehension, a major tenet of informed consent. They lacked awareness and understanding of their situation and possibilities. From our data, it appears that provider bias may affect the opinion of some patients, with undue influence on patient’s voluntary decision making.”

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‘Failure to progress’ new tool to monitor labour may reduce caesarean rate

‘Failure to progress’ (dystocia) is one of the most common reasons women are given during labour for the need to resort to a caesarean despite the fact that “…no precise definition of dystocia exists.” Hospital policies or individual practise therefore tend to dictate what is acceptable in any given hospital setting. In actual fact if mum and baby are showing no signs of distress, this diagnosis should not be used as justification for a caesarean, though it often is.

This is where knowing just that little bit more about birth ‘complications’ (not that ‘failure to progress’ is a complication) and rights versus hospital policies can make all the difference to whether or not you have the birth you hope for, assuming of course you are simply progressing slower than expected.

Incredibly studies from the 1950s which suggested that cervix dilation was a linear process (dilation = 1.2cm per hour) are still being referred to as ‘normal’ progress today. New research from Ohio State University suggests not only that the progress if not linear but that they have found a way to more accurately access labour progress for first time mothers. The tool, a partographer, “is a printed graph on which a clinician can plot cervical dilation and the baby’s descent to determine whether labor is progressing normally or if intervention might be needed.”

The researchers predict that “if their partograph were adopted widely in the United States, dystocia diagnoses would be limited to only the slowest 10 percent of first-stage labors; oxytocin interventions would drop by more than 50 percent; and cesarean sections performed because of dystocia would decrease by more than 50 percent.”

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Diabetes – oxytocin less effective for these women

For years now diabetes has been known to complicate birth for many women and unfortunately the incidence of ‘type two diabetes’ is increasing as our weight as a nation increases.

According to researchers at the University of Liverpool approximately 60% of diabetic women (including those who develop diabetes during pregnancy) will be unable to complete labour naturally and will require a caesarean.

Until now the reason for this has not been fully understood. Researchers have found “that contractions in women who had the disease were not as strong as those in non-diabetic women…Calcium levels in the uterus should rise to allow the muscle to contract effectively. Researchers found, however, that in women with diabetes, calcium levels are significantly reduced. “ University press release

While the result itself is useful in understanding why this is happening to so many of the 35,000 women that have diabetes during pregnancy every year, the implications for the management of diabetic labours is perhaps even more significant.

Researchers found that when uterine tissue of diabetic women was treated with oxytocin (a drug often used to assist labours that are experiencing difficulties) it was found that contractions “failed to reach the same levels of contractility as in non-diabetic women.” While more research is on-going, this finding does suggest that advice to women as they plan their birth ought to consider caesarean birth as a prophylactic option and more specifically for those wishing to attempt labour that the door is left open to switching to a caesarean during labour earlier such that they can have a caesarean before real signs of distress result in ‘critical’ surgical intervention.

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Words of wisdom from Betty Parson’s – childbirth guru

Betty died this week but left wonderful words that we would all do well to take with us into our births and into life in general…

“It is the attitude of mind that is the most important thing of all…to be able to go into labour [or indeed any type of birth or life situation] with the positive attitude ‘I am doing’ rather than ‘it is being done to me’.”

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Options after a previous caesarean

I frequently get asked about options following a previous caesarean. Unfortunately the answer is not straightforward. Hospital policies continue to influence things both overtly in terms of encouragement towards VBACs (Vaginal Birth After Caesarean) and whether or not there is a ban on requested caesareans, but also less overtly through their common practises e.g. their approach to induction / tolerance for the length of 2nd stage labour etc. In addition to hospital policies there are also differences of opinion among practitioners which can alter the options you may be presented with on any given day.

It is very important therefore that you know your rights. “Calmly discussing your options, knowing what can and cannot be insisted upon and the difference between a ‘required’ and ‘suggested’ caesarean, puts you in a strong negotiating position.” ‘Caesarean Birth: A positive approach to preparation and recovery’

Trying to avoid a caesarean:

For those wanting to avoid automatically having another caesarean this is increasingly possible, always assuming of course that the reason for the first caesarean is not likely to recur in each pregnancy. Hospitals are being actively encouraged to support VBACs and NICE guidelines state that “Women have the right to choose VBAC.” (pg 22)

Some hospitals offer special clinics aimed at encouraging just this. It is worth asking what is available at your hospital and local doctor surgery as these classes can provide lots of information and support about how to manage your pregnancy and labour such that you may increase your chances of achieving a vaginal birth.

If you continue having difficulty gaining agreement for a VBAC it is worth knowing that the NICE guidelines are very clear on this “For the process of seeking consent to be meaningful, refusal of treatment needs to be one of the patient’s options. Competent adults are entitled to refuse treatment even when the treatment would clearly benefit their health. Therefore a competent pregnant woman may refuse CS, even if this would be detrimental to herself or the fetus.” (pg 71 )

That said it is very important that you understand why a VBAC is not being supported this time round. Just a few examples of the reasons are: there may be genuine medical indicators meaning this is not the safest route for this pregnancy, the practitioner is less confident with VBACs (in which case you may want to consider alternative providers) or you are hearing a practitioners personal opinion coloured by fears of scar rupture rates. I dedicate a whole chapter in my caesarean book to the many things you can try in order to help influence your chances of avoiding another caesarean. In particular I address the mis-information often presented to women on scar rupture rates so that you can make an informed decision about the level of risk yourself.

Requesting a repeat caesarean

For those preferring to have another caesarean this will, in many cases, be dependent upon the opinion or policy of those responsible your care. Some hospitals do not permit maternal request caesareans, even after a previous one, if there is no medical need. (A previous caesarean no longer constitutes a ‘medical need’, unless as already mentioned, your first caesarean was for reasons which are likely to recur in this pregnancy). Where your request is being refused you will need to seek a second opinion and may even (if the opinion is a hospital policy rather than the personal opinion of the practitioner you are talking to) need to approach a different hospital.

The NICE guidelines are very clear on this:

“Recommendation 39: An obstetrician has the right to decline a woman’s request for a CS. If this happens, they should refer the woman to an NHS obstetrician in the same unit who will carry out the CS.” NICE guideline (pg 12)

However the guidelines are just that – ‘guidelines’. NHS hospitals are not required to follow them to the letter so you may find you are requesting a caesarean at a hospital where maternal requests, in the absence of any medical need, are indeed banned in which case you will need to seek an alternative place to deliver.

I talk in a lot more detail in my caesarean book about things to know if you want to avoid or indeed plan a caesarean. In both cases you may find significant barriers are put in your way, but there are quite a lot of things you can do to help you case.

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